Synthesis, Characterization, Antimicrobial Activity and Molecular Docking of a Dinuclear Nickel(II) Complex
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Abstract
Bis-(benzidinedioxime) nickel(II) acetate complex was synthesizedby reacting the metal ions with benzidinedioxime in 1:1 mole ratio.The nickel(II) complex was characterized by elemental analysis, NMR, and powder X-ray diffraction. The result obtained from CHN Elemental analysis and 1H nuclear magnetic resonance confirmed that the nickel(II) complex is synthesized by reacting benzidinedioxime with nickel(II) acetate in a 1:1 mole ratio. The powder XRD showed that two Ni(II) coordinated to two benzidinedioxime ligands via the nitrogen atoms of both oxime groups and the two azomethine nitrogen atoms. Powder X-ray diffraction (PXRD) indicated that the nickel(II) complex has little distorted tetrahedral geometry. Nickel(II) complex has a higher antimicrobial activist against K. pneumonia, B. subtilis, and Candida than kanamycin. In addition, the B. subtilis shows resistance against kanamycin (inhibition zone 0) while it shows high sensitivity against bis-benzidinedioxime nickel(II) acetate complex (inhibition zone 33.3 ± 0.82 mm, MIC 18.5 µg/mL). The average MICs of bis-benzidinedioxime nickel(II) acetate are found to be for inhibition of each of the five organisms in the range of 6.2–55.65 µg/mL. The molecular docking studies investigations confirmed that the bis-benzidinedioxime nickel(II) acetate is the most potent aminoglycoside enzymes bacterial inhibitors. The bis-benzidinedioxime nickel(II) acetate exhibited high binding energy with the receptor aminoglycoside-3-phosphotransferase enzyme than receptors of other aminoglycoside enzymes families.
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